In typical, business-first fashion, their corporate overlords marvel at the notion of mass-manufacturing it, and promptly reject Elsa's proposition of human experimentation (to cure genetic disorders). Clive (Brody) and Elsa (Polley) are young scientists who have made a breakthrough in artificial life: two blob-like creatures (one male, one female) with the ability to manufacture an artificial protein for the purpose of nourishing livestock. There are missteps along the way, but for the most part, this is a solid little sleeper.

For a while, the film plays like something closer to an art-house feature (especially given the presence of character actors like Adrien Brody and Sarah Polley) with intriguing ideas and a solid FX budget. Many have already drawn comparisons (both positive and negative) to the early, mutation-informed works of Canadian auteur David Cronenberg, but Natali is just as interested in exploring the questions under the surface as he is showing an astutely creative visual eye. Vincenzo Natali's 'Splice' falls somewhere within this noteworthy pantheon of mad science, moral/ethical conundrums, and icky special effects. And rounding out this prolific bunch is David Lynch's 'Eraserhead,' a hauntingly surreal horror film that not only presents parenthood with fearful uncertainty, but treats acts of sexuality and procreation with a metaphorically clinical (but never explicit) disgust.

Larry Cohen's 'It's Alive' took contemporary paranoias of a carcinogen-engulfed atmosphere and nuclear proliferation and applied it to his own murderous, bloodthirsty infant. Roman Polanski evolved this idea (via adaptation of Ira Levin's novel) in 'Rosemary's Baby,' which took the notion of creating something truly awful (the son of Satan) and using it as a metaphor for a woman's self-destruction and paranoia during pregnancy. James Whale's 1931 adaptation of Mary Shelley's 'Frankenstein' was one of the earliest films to chronicle man's quest (via science and nature, and in notably strict defiance of God) to literally create life by transgressing human reproduction granted, the result was the hideous, hulking visage of Boris Karloff, but one couldn't help but be in awe of the sheer gumption of Victor Frankenstein and his accomplices.

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